Tripeptidyl peptidase



Tripeptidyl peptidase (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides. TPP-I functions in lysosomes, TPP-II is part of the ubiquitin-proteasome pathway. The images at the left and at the right correspond to one representative TPP, i.e. the crystal structure of Pro-Tripeptidyl peptidase-IV from Porphyromonas gingivalis (2d5l).

TPP-I
3ee6 – TPP-I – human

3edy – hTPP-I precursor residues 20-563

TPP-II
3lxu – TPP-II residues 463-770 – Drosophila melanogaster

TPP-IV
2eep – PgPro-TPP-IV+inhibitor – Porphyromonas gingivalis

2d5l - PgPro-TPP-IV

2z3w - PgPro-TPP-IV (mutant)

2z3z, 2dcm - PgPro-TPP-IV (mutant)+inhibitor